In this meta-analysis of randomized controlled trials of CRT in patients with any degree of symptoms and EF<40%, CRT was beneficial in patients in with Class I-II CHF symptoms, with lower all cause mortality and CHF hospitalizations, but no improvement in functional status or quality of life. There is evidence that CRT improved outcomes in patients not only with CHF Class III-IV, but also with Class I-II. However, CRT is associated with the risks of infection (1.4%) leasd problems (6.2%) mechanical complications (3.2%) and procedure-related deaths (0.3%) (abstract)
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