In this trial of >300 patients with ACS/STEMI receiving ASA + plavix, and enoxaparin or thrombolytics, they were randomized to PPI or H2 blocker therapy. After a mean follow up of ~4 months, only 1 patient in the PPI group and 9 patients in the H2 blocker group developed an UGI bleed. PPIs are better than H2 blockers in preventing UGI bleeding in patients on combination anti platelets and anticoagulants (abstract)
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