In this multicenter trial of intubated patients on sedation protocols, they were randomized to daily sedation interruption, or no additional intervention. There were no difference between the groups in time to successful intervention, ICU LOS, hospital LOS, delirium rates, or rates of unintentional extubation. The daily interruption group was associated with higher daily doses of opiates and benzodiazepines, and higher nursing workload. Daily sedation interruption, when added to sedation protocols, and no better than sedation protocols alone (abstract)
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