This trial of almost 1,000 patients with acute upper GI bleeding randomized them to a restrictive (Hb<7) or liberal (Hb<9) transfusion strategy. Only 15% of the liberal, and 51% of the restrictive group did not receive a transfusion; 6 week survival was higher in the restrictive group (95% vs 91%), recurrent bleeding was lower (10% vs 16%), and adverse events were lower (40% vs 48%). A restrictive transfusion strategy should be applied to patients with acute UGI bleed (abstract).
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