In this meta-analysis of 8 randomized trials involving 1726 patients, BNP-guided CHF management reduced overall mortality (compared to usual care), but did not reduce hospitalizations. Those in the BNP guided groups were more likely to achieve target doses of beta blockers and ACE inhibitors (which is likely causally related to the reduction in mortality). BNP guided CHF management may have role in the outpatient setting to get patients to target doses of medications, but does not reduce hospitalization rates (abstract)
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