In this trial of 161 pediatric patients in an ED with skin/soft tissue infections (of which 80% were CA-MRSA), after incision and drainage, they were randomized to 10 days of placebo or antibiotics (trimethoprim-sulfamethoxazole). Ten day treatment failure was similar between the groups (5% and 4%) as was 30 day lesion recurrence (29% and 28%). There does not appear to be an advantage to antibiotics after incision and drainage of MRSA skin and soft tissue infections (abstract).
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