In this multi-center RCT, over 700 patients with EGD-proven bleeding peptic ulcers were randomized (after endoscopy) to 72 hours of IV PPI (80mg bolus, then 8mg/hr) or placebo. Those in the PPI group had less recurrent bleeding at 72 hours (6% vs 10%) and less endoscopic re-treatment (6% vs 12%), surgery (3% vs 5%), and death (1% vs 2%). Of note, this only applies to post-endoscopy bleeding peptic ulcers, and does not address either oral PPI therapy, or pre-endoscopy PPI therapy (abstract).
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