There is mounting evidence that PPI use is associated with higher risk for a number of infectious diseases (including clostridium difficile, SBP, and pneumonia). In this large prospective cohort, researchers examined the strength of association between PPIs and hospital acquired pneumonia (HAP), and found a 30% higher risk of HAP in those on PPIs than those not on PPIs (after multivariable adjustment). They did not find a significant association with H2 blockers (abstract). Over half of the inpatients received an acid suppressive medication during their inpatient stay. This study adds to the existing literature of the overuse and potential harm of acid suppressive medications in inpatients.
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