For hospitalized patients on chronic methadone, these new guidelines help aid us in decision making, based on the patient’s QT interval (guidelines). Of the highlights, they recommend if the QT is >500 ms, we should consider reducing or discontinuing the methadone (the QT prolonging effect is dose-dependent), and discontinuing any medications that promote hypokalemia. They also recommend vigilence in starting new drugs with QT prolonging potential (website list)
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