In thistrial of 120 healthy volunteers, they were randomized to 12 weeks of placebo or 8 weeks of PPI followed by 4 weeks of placebo. GERD symptoms were similar in the first 8 weeks, but in weeks 9-12, symptoms were significantly higher in the former PPI group (44% versus 15%) indicating significant post-PPI rebound. This is another reason to avoid unnecessary PPIs in inpatients, as many will experience rebound symptoms after cessation (abstract).
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