In this large randomized trial of patients with acute DVT, rivaroxaban (oral Xa inhibitor) was non-inferior to lovenox (bridged to coumadin) in the primary outcome of recurrent DVT, with the same incidence of bleeding. After 6-12 months of treatment, those that continued on rivaroxaban had significantly fewer recurrent DVTs than those that continued on placebo. Rivaroxaban is non-inferior to lovenox/warfarin for acute DVT, and better than placebo for ongoing longer term treatment (abstract). It is not currently FDA approved in the US but is under review.
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