In this large trial of 4832 patients with PE, they were randomized to rivaroxaban (15mg bid for 3 weeks, then 20mg qday) or enoxaparin-warfarin. Recurrent VTE occurred at about the same rate in both groups (2.1% of rivaroxaban group and 1.8% of enoxaparin-warfarin group), but major bleeding was less common with rivaroxaban (1.1% vs 2.2%). Pending FDA approval, rivaroxaban may become the new standard for VTE treatment (abstract)
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